Metabolism of D-cephaloglycin-14C and L-cephaloglycin-14C in the rat.

نویسندگان

  • H R Sullivan
  • R E Billings
  • R E McMahon
چکیده

The fate of the orally effective antibiotic D-cephaloglycin and its much less active L-enantiomer has been studied in the rat. D-Cephaloglycin-14C is metabolized by two pathways, (1) hydrolysis of the amide linkage to form D-2-phenylglycine-14C and (2) deacetylation to form deacetyl-D-cephaloglycinUC. D-Cephaloglycin is absorbed from the gastro-intestinal tract at least in part as the intact antibiotic, L-Cephaloglycin-uC is rapidly metabolized to L-2-phenylglycine-14C and its metabolites. In contrast to the results with dcephaloglycin-uC, no intact L-cephaloglycin-uC or deacetyl-L-cephaloglycin was excreted in the urine of rats.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 22 1  شماره 

صفحات  -

تاریخ انتشار 1969